For me, a "loser" is someone with no drive, or someone who keeps bungling up whatever he/she has going for him/her.....so in short, you can have no friends, be dirt poor, no job but not be a loser if you're at peace with your life, and are actually happy..... conversally, even if you have a lot going for you, but don't have drive or a bad attitude, you're still a loser in my book :)